It takes two to stop chronic pain: an innovative treatment with endogenous regulatory immune molecules

Chronic pain – pain that exists longer than 3 months - is a major clinical problem affecting up to 20% of the population. Current treatment options for pain are often ineffective and with severe side effects. Applicants did the surprising discovery that molecules that regulate the immune system, i.e. cytokines, also regulate endogenous pain resolving pathways. Based on these new insights they designed a strategy to effectively resolve pain by using fusion proteins of two cytokines, termed synerkines. Proof of this new concept was generated with a prototypic synerkine in multiple animal models for chronic pain. In this project applicants will tailor the structure and composition of synerkines for specific types of chronic pain. Furthermore, they will define the mechanism of action of synerkines to resolve debilitating chronic pain conditions. Deliverables of the project will be licensed out to a new company dedicated to develop synerkines for clinical and commercial applications.

  • Projectnummer / Project number: 16907
  • Deelnemende kennisinstellingen / Participating institutes: Universitair Medisch Centrum Utrecht
  • Gebruikers / Users: 2 bedrijven , 1 medisch centrum en 1 eindgebruiker / 2 companies, 1 medical center and 1 end user
  • Projectleider / Project leader: Dr. N. Eijkelkamp, Universiteit Utrecht, Universitair Medisch Centrum Utrecht
  • Type project / Type project: Lopend
  • Startdatum / Start date: 1-09-2019
  • Einddatum / End date: 31-08-2023
  • Programma / Programme: Open Technologieprogramma
  • Vakgebied / Discipline: Life science


Dhr. dr. R. (Rob) Hermans (Programmamedewerker) Dhr. dr. R. (Rob) Hermans (Programmamedewerker) 030 6001 317