DEtection and MOnitoring of treatment of BACTerial infections with Optical Imaging and Positron Emission Tomography (DEMO-BACT)

Bacterial infections are a frequently occurring problem in almost all medical disciplines. The incidence is rising due to an increasingly ageing population, increased use of implanted materials, an increase in the use of intensive chemotherapeutic possibilities, a more frequent use of immunosuppressive medication, and an increased bacterial resistance to antibiotics. Many infections can be treated if diagnosed accurately at an early stage, when major damage has not yet occurred. For current imaging techniques the discrimination between bacterial infection and other disease states, such as a normal inflammatory response due to the injury, fracture healing, or the operation is a major challenge. Our proposed solution to this problem is a specific methodology of bacteria-targeted imaging. Targeted bacterial imaging would not only allow for specific non-invasive imaging of infection, but might also discriminate between different microorganisms. We aim to develop labelled vancomycin as targeted bacterial imaging agent for clinical application.

  • Projectnummer / Project number: 16895
  • Deelnemende kennisinstellingen / Participating institutes: UMC Groningen
  • Projectleider / Project leader: Prof. dr. P.H. Elsinga
  • Type project / Type project: Initieel
  • Startdatum / Start date: 09-11-2018
  • Einddatum / End date: 01-09-2023
  • Programma / Programme: Open Technologieprogramma
  • Vakgebied / Discipline: Geneeskunde