Development of deuterium metabolic imaging to map body biochemistry with MRI

The global obesity epidemic has resulted in a dramatic rise in metabolic diseases. Unfortunately, our understanding of the derangements in body metabolism in these diseases is far from complete, which has limited the development of effective therapies. In this project, we propose to develop a completely novel, non-invasive imaging technique to dynamically map body metabolism, namely deuterium metabolic imaging (DMI). DMI is based on the detection of deuterium with MRI after oral intake of deuterated precursor molecules, such as deuterated glucose or heavy water. The objectives of the project are: (1) Build and test a body DMI setup for a clinical ultra-high field 7 tesla MRI scanner; (2) BodyDMI 3 develop DMI sequences, motion correction and data analysis techniques; (3) demonstrate proof of concept to measure hepatic glycogen synthesis and de novo lipogenesis; and (4) apply DMI in a clinical feasibility study in type 2 diabetes patients. Upon successful completion of the project, DMI will be valorized by the commercial partners and embedded in clinical practice enabling clinical studies in the field of metabolic diseases, oncology, drug toxicity and organ failure. DMI will become a valuable tool for drug studies to directly image their chemical efficacy in a personalized manner

  • Projectnummer / Project number: 17134
  • Deelnemende kennisinstellingen / Participating institutes: Universitair Medisch Centrum Utrecht (UMCU)
  • Projectleider / Project leader: Dr. J. J. Prompers - Universitair Medisch Centrum Utrecht (UMCU) Afdeling Radiologie, High Field MRI groep
  • Type project / Type project: Lopend
  • Startdatum / Start date: 01-02-2019
  • Programma / Programme: High Tech Systemen & Materialen (HTSM)
  • Vakgebied / Discipline: Technische wetenschappen, Levenswetenschappen, Geneeskunde


Contact

Mw. dr. W. (Wieke) Haakma (Programmamedewerker) Mw. dr. W. (Wieke) Haakma (Programmamedewerker) 030-6001296 w.haakma@nwo.nl