Mining Rhizopus genomes

Samenvatting

Comparison of genome organization between different fungi will help to shed light on the fundamental question how genome organization influences evolutionary processes and the emergence of important phenotypes such as pathogenicity. Due to recent developments in high-throughput sequencing, datasets on whole genome sequences and gene expression are publicly available. However, extensive background knowledge on molecular and infection biology of the fungi under study is invaluable for the interpretation of comparative genomics results. The objective of this visit is to uncover the genomic organization and dynamics and identify genes potentially involved in virulence in Rhizopus, a genus of zygomycete fungi. Rhizopus is widely known as a saprotroph on plants, causing post-harvest diseases that lead to great agricultural losses, and as an opportunistic pathogen on humans, causing aggressive infections in immunocompromised patients with a high mortality rate. Rhizopus not only causes harm: it is widely used in production of proteins and secondary metabolites and in the preparation of Asian traditional fermented foods. The host group has developed a suite of bioinformatic tools that it has mainly applied to genomic analysis of the fungus Fusarium oxysporum and now wishes to expand its horizon and apply the toolset that it developed to other fungal species.

Kenmerken

Projectnummer

040.11.713

Hoofdaanvrager

Dr. M. Rep

Verbonden aan

Universiteit van Amsterdam, Faculteit der Natuurwetenschappen, Wiskunde en Informatica, Swammerdam Institute for Life Sciences (SILS)

Looptijd

01/07/2019 tot 30/09/2019