Nutrition, the unrecognized determinant in Alzheimer?s disease (NUDAD)

Samenvatting

Diet likely has an important effect on cognitive health and performance. The most common form of dementia, Alzheimer?s disease (AD), is one of the grand challenges of the 21st century. Prevention of dementia through dietary intervention is an attractive approach, especially since curative therapy is not available now or in the near future. Dietary intervention is relatively safe and cheap, compared to drug development and treatment, but should be based on scientific evidence of the factors involved. NUDAD?s main objective is to identify modifiable dietary risk factors for AD, the preceding stages of mild cognitive impairment (MCI) and preclinical AD (i.e. cognitively normal) in a longitudinal cohort study.
We will assemble a prospective cohort of patients at risk of AD (cognitively normal, MCI) and mild AD, with clinical follow-up during three years. In these patients, we will measure food behaviour including taste, smell, hunger /satiety and food preference as determinants of food intake, track food intake using detailed questionnaires, measure energy needs and body composition, and assess nutritional biomarkers in patients? blood and CSF. These findings will be used to identify risk factors for AD, formulate dietary guidelines for patients with (predementia) AD and to develop recommendations for trial design in stratified patient groups. Ultimately, this will aid in the future development of targeted nutritional products for patients (at risk of) cognitive decline and AD.

Output

Proefschrift

  • beoogd: proefschrift

Wetenschappelijk artikel

  • M. de van der Schueren, S. Lonterman-Monasch, W.M. van der Flier, M.H. Kramer, A.B. Maier, M. Muller(2016): Malnutrition and risk of structural brain changes on MRI in geriatric outpatients Journal of the American Geriatric Society (JAGS) pp. 2457 - 2463
  • J. Hertel, J. van Dongen, Q. Yang, K. Fisher, N. Friedrich, L. Weinhold, H. Wagner, S. Li, W. Maier, M. Perola, A. Metspalu, D.I. Boomsma, A. Ramirez, V. Salomaa, P.E. Slagboom, K. Willems van Dijk, M. Wagner, J. Hernesniemi, J. Tynkkynen, R.E. Gertzen, F.A. de Leeuw, A. Verhoeven, N. Amin, C.E.M. Beijsterveldt, M.A. Ikram, M. Pietzner, C.F.W. Peeters, M. Kivimäki, W.M. van der Flier, R. Pool, S.J. van der Lee, A. Singh-Manoux, G. Willemsen, S. Seshadri, M.J. Shipley, P. Scheltens, C.M. van Duijn, T. Haller, K. Budde, H. Jörgen Grabe, D. Melo van Lent, C.E. Teunissen, R.S. Vasan, V. Chouraki, S. Egbert, T. Hankemeier, A. Teumer(2017): Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies Alzheimers Dement pp. 707 - 722
  • F.A. de Leeuw, P. Scheltens, C.M. van Duijn, C.F.W. Peeters, M.I. Kester, S.J. van der Lee, A.C. Harms, C.E. Teunissen, W.M. van der Flier, E.A. Struys, M.A. van der Wiel, H.W.T. van Vlijmen, T. Hankemeier, A. Demirkan(2017): Blood-based metabolic signatures in Alzheimer's disease Alzheimers Dement (Amst) pp. 196 - 207

Publicatie bedoeld voor een breed publiek

Kenmerken

Projectnummer

057-14-004

Hoofdaanvrager

Prof. dr. W.M. van der Flier

Verbonden aan

Vrije Universiteit Amsterdam, VU Medisch Centrum Amsterdam

Uitvoerders

A. Doorduijn, J.L.P. Fieldhouse, J.M. Overbeek, Drs. F.A. de Leeuw

Looptijd

01/06/2015 tot 15/07/2019