Biomarker Development Center (Biomarker-DC)

The programme Biomarker Development Center had the mission of further investigating potential biomarkers and making these suitable for large-scale use. Biomarkers are substances used to mark a specific biological state and with this to recognise a medical condition.

Many candidate biomarkers have now been discovered through research, but a lot of these require further clinical investigation. This programme aimed to develop ultrasensitive analytical methods to encourage and simplify this research. These methods focussed on areas within three major diseases: COPD (Chronic Obstructive Pulmonary Disease), Alzheimer’s and type II diabetes. To make optimal use of the expertise and findings from the various analytic laboratory and clinical centres a so-called open innovation network was formed; the Biomarker Development Center. Highly promising biomarkers were validated here in close collaboration with several university medical centres with the aim of further developing robust biomarkers for these diseases into clinical tests.

Programme leader

Prof. dr. R.P.H. Bischoff, Rijksuniversiteit Groningen

2013 Perspectief Biomarkers (klein).jpg
The image shows a diagram of a data plot as it comes from a biomarker project. The peaks are signals that come from the measurements. Changes in the intensity of these signals gives an indication that a certain molecule is changing in concentration, for example due to a disease. This is where the biomarker validation begins, the main topic of the BDC.


  • High throughput sample preparation and MALDIMS/MS mass spectrometry - prof. dr. R.P.H. Bischoff, Rijksuniversiteit Groningen (project number: 13541)
  • High-sensitivity LC-MS/MS and Phosphoproteomics - dr. T.M. Luider, Erasmus Universiteit Rotterdam (project number: 13542)
  • Improved Immunoassay Methodology - prof. A.J. van Gool, Radboud Universiteit Nijmegen (project number: 13543)
  • COPD Demonstrator - dr. N.H.T. ten Hacken MD, Rijksuniversiteit Groningen (project number: 13544)
  • Alzheimer’s Disease Demonstrator - dr. T.M. Luider, Erasmus Universiteit Rotterdam (project number: 13545)
  • Diabetes Demonstrator - prof. dr. C.J.J. Tack, Radboud Universiteit Nijmegen (project number: 13546)    


Ampt, Kirsten.jpg

Dr. Kirsten Ampt

+31 (0)30 6001370

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