Inhibitors of the human kinase PKB/Akt: conceptually new antibiotics

Summary

The human kinase PKB/Akt1 controls infection of Salmonella typhimurium and Mycobacterium tuberculosis and is essential in the development of many tumours. I will develop potent and selective PKB/Akt1 inhibitors, and I will apply chemistry, biochemistry and cell biology to reach this goal: blocking a kinase essential in many diseases.

Output

Scientific article

  • PPP Geurink, N Liu, MPMP Spaans, HS Overkleeft(2010): Incorporation of fluorinated phenylalanine generates highly specific inhibitor of proteasome's chymotrypsin-like sites Journal of medicinal chemistry pp. 2319 - 2323

Details

Project number

017.006.040

Main applicant

Dr. N. Liu

Affiliated with

Universiteit Leiden, Faculteit der Wiskunde en Natuurwetenschappen, Leiden Institute of Chemistry

Team members

Dr. N. Liu

Duration

01/09/2009 to 05/06/2014