The polar compounds identification tool: a 4000 QTrap LC-MS/MS

Summary

In interactions between abiotic and biotic components of ecosystems, or between biotic components mutually, the role of organic chemicals is essential. For example, plants communicate with their environment through organic compounds. Herbivorous insects and mites use chemicals to orient themselves when selecting food sources, or to find partners. Plants protect both their above-ground and below-ground parts against herbivorous arthropods by producing specific signaling chemicals, that attract natural enemies of the predators. Upon release to their direct environment, the chemicals are subjected to various processes in air, water, or soil. To what extent the abiotic factors affect the plant?s control of the signaling process, or even render secondary, is still unknown. Infochemicals released below ground are likely to be less volatile, more polar and water soluble than those released above ground.
Substances can also cause stress to individuals, populations, or ecosystems. Both natural and anthropogenic chemicals can cause stress. Whether or not stress (effects) will occur, and to what extent, depends on biotic and abiotic environmental factors. For example, for the transport and distribution in the soil compartment, moisture content is an essential factor. In aqueous systems partitioning (sorption, volatilization), or the behavior of the organisms are highly important for the (bio)availability, and hence the potency to exert effects in organisms. Polar organic compounds intrinsically are more mobile than non polar ones, but can be immobilized temporarily or permanently through sorption to organic material present in the soil or in the dissolved phase. The bioavailability, in turn, is a major determinant for the degradability, and hence the persistence of the compound in the soil or water compartment. Degradation products usually are more polar than their parent compounds.
Until know, the structure of dissolved organic matter in soils and surface waters remains poorly characterized. This not the least so because of a lack of proper analytical equipment suited for structure elucidation of these polar organic materials.

The research of the Institute for Biodiversity and Ecosystem Dynamics (IBED) integrates disciplinary concepts into multidisciplinary ecosystem studies. IBED investigates the character and fate of infochemicals, stress chemicals and abiotic components of organic materials in soils and water in order to better understand how organisms communicate in ecosystems, how they cope with stress, and to what extent environmental conditions influence such processes. For this type of studies monitoring of identities and quantities of compounds involved in these processes is essential. Characterizing the identity of polar organics, their degradation products, and components of organic material (C, N) is fundamental and innovative for the areas of ecology of infochemicals, environmental chemistry of stress chemicals, and structure elucidation of organic matter in environmental compartments.

Over the years the IBED laboratory has built up equipment to study the fate of anorganic and persistent organic compounds in ecosystems. Considering the developments outlined above, IBED?s ambition is to extend this equipment with an instrument specifically suited for qualitative and quantative analysis of polar organic compounds. Because of the reasons mentioned, the instrument must satisfy high specificity, selectivity and sensitivity demands.
The 4000 Qtrap LC-MS/MS instruments particularly meets these requirements. Combining the expertise in the areas of mass spectrometry, liquid chromatography, soil and aquatic sciences, and population biology from the UvA institutes involved will enable the development of a very powerful instrumentarium for the earth and life sciences.

Output

Book or monography

  • (2006): Estrogens and xenoestrogens in the aquatic environment: An integrated approach for field monitoring and effect assessment pp. 512 , Pensacola (FL)
  • W.P. de Voogt(2010): Perfluorinated alkylated substances. pp. 222 , New York

Chapter in book

  • P. de Voogt(2006): Alkylphenol ethoxylates and alkylphenols in the aquatic environment of The Netherlands pp. 77 - 99 , Pensacola (FL)
  • R.W.P.M. Laan, P. de Voogt, M.H. Bik(2006): Assessment of Organic Compounds in the Rhine Estuary pp. 307 - 368 , Berlin
  • J.R. Parsons, M.J. Belzunce Segarra, G. Cornelissen, O. Gustafsson, T. Grotenhuis, H. Harms, C.R. Jansen, J. Kukkonen, P. van Noort, J.J. Ortega Calvo, O. Solaun Exteberria(2007): Characterisation of contaminants in sediments - effects of bioavailability on impact pp. 35 - 60 , Amsterdam
  • T.P. Knepper, C. Eschauzier, W.P. de Voogt, H.J. Brauch, F.T. Lange(2011): Handbook of Environmental Chemistry pp. 73 - 102 , Heidelberg
  • TP Knepper, C Eschauzier, W.P. de Voogt, HJ Brauch, FT Lange(2011): Polyfluorinated chemicals and transformation products pp. 73 - 102 , Heidelberg
  • G. Shimmield, R.W.P.M. Laane, D. van de Meent, W.P. de Voogt, J.R. Parsons, J. Hendriks, J. van Gils(2012): Treatise on Coastal and Estuarine Science pp. 161 - 203 , amsterdam

Scientific article

  • W.P. de Voogt, HAJ Govers, N Jonkers(2005): Adduct formation in LC-ESI-MS of nonylphenol ethoxylates: mass spectrometrical, theoretical and quantitative analytical aspects. Anal. Chim. Acta pp. 217 - 228
  • M Sáez, W.P. de Voogt(2006): Analytical chemistry of perfluoroalkylated substances Trends Anal. Chem. pp. 326 - 342
  • P. de Voogt, U. Berger, W. de Coen, W. de Wolf, E. Heimstad, M. McLachlan, S. van Leeuwen, A. van Roon(2006): Perfluorinated organic compounds in the European environment Report to the EU pp. 1 - 132
  • A. van Roon, W. Fahner, Yi Chen, P. de Voogt(2006): Partitioning of perfluorinated alkylated substances between water and sediment in field and laboratory experiments Organohalogen Compounds pp. 671 - 674
  • P. de Voogt, M. Sáez(2006): Analytical chemistry of perfluoroalkylated substances Trends Anal. Chem. pp. 326 - 342
  • A.D. Vethaak, S.M. Schrap, P. de Voogt(2007): De vrouwelijkheid van mannetjesvissen: meten is weten (Femininity of male fish; to measure is to know) Trends in Water pp. 8 - 9
  • P. de Voogt, U. Berger, W. de Coen, W. de Wolf, E. Heimstad, M. McLachlan, S. van Leeuwen, A. van Roon(2007): Perforce: perfluorinated organic compounds in the European environment - Achievements of the PERFORCE project. Organohalog. Compds. pp. 153 - 156
  • P. de Voogt, F.W.M. van der Wielen, J. Westerveld, W. D'Hollander, L. Bervoets(2008): Determination of perfluorinated organic compounds in food and dust Organohalog pp. 714 - 717
  • JR Parsons, M Sáez, W.P. de Voogt(2008): Persistence of perfluoroalkylated substances in sludge and sediment Environ. Sci. Pollut. Res. pp. 472 - 477
  • M.G. de Vos, M.A.J. Huijbregts, M.J. van den Heuvel-Greve, A.D. Vethaak, K.I. van de Vijver, P.E.G. Leonards, S.P.J. van Leeuwen, P. Voogt, A.J. Hendriks(2008): Accumulation of perfluorooctane sulfonate (PFOS) in the food chain of the Western Scheldt estuary. Comparing field measurements with kinetic modeling Chemosphere pp. 1766 - 1773
  • JR Parsons, J Dolfing, W.P. de Voogt, M Sáez(2008): Biodegradation of Perfluorinated Compounds. Rev. Environ. Contam. Toxicol. pp. 53 - 71
  • M. Saéz, P. de Voogt, J.R. Parsons(2008): Persistence of perfluoroalkylated substances in sludge and sediment Environ. Sci. Pollut. Res. pp. 472 - 477
  • W.P. de Voogt, et al, N Johansson(2008): Contaminants in the Food Chain on PFOS, PFOA and their salts. EFSA Journal pp. 1 - 131
  • AJ Hendriks, PEG Leonards, SPJ van Leeuwen, MG de Vos, AD Vethaak, MJ van den Heuvel, MAJ Huijbregts, W.P. de Voogt, KI Vandenvijver(2008): Accumulation of perfluorooctane sulfonate (PFOS) in the food chain of the Western Scheldt estuary. Chemosphere pp. 1766 - 1773
  • J.R. Parsons, M. Saéz, J. Dolfing, P. de Voogt(2008): Biodegradation of Perfluorinated Compounds Rev. Environ. Contam. Toxicol. pp. 53 - 71
  • W.P. de Voogt, PM Visser, E van Donk, S Cerbin, MHS Kraak(2010): Combined and single effects of pesticide Carbaryl and toxic Microcystis aeruginosa on the life history of Daphnia pulicaria Hydrobiologia pp. 129 - 138
  • C Eschauzier, W.P. de Voogt, J Haftka, PJ Stuyfzand(2010): Perfluorinated compounds in infiltrated river Rhine water and infiltrated rainwater in coastal dunes. Environ. Sci. Technol. pp. 7450 - 7455
  • J Westeveld, R Ebinghaus, A Möller, R Surm, F van der Wielen, L Ahrens, W.P. de Voogt(2010): Distribution and sources of polyfluoroalkyl substances (PFAS) in the River Rhine watershed Environ. Pollut. pp. 3243 - 3250
  • A Covaci, W.P. de Voogt, C Cornelis, K van Campenhout, L Bervoets, L Roosens, H Reynders, W D'Hollander(2010): Brominated flame retardants and perfluorinated compounds in indoor dust from homes and offices in Flanders, Belgium Chemosphere pp. 478 - 487
  • M. Schriks, M.C. Heringa, W.P. de Voogt, A.P. van Wezel(2011): Response to Mario Schirmer, Marion Martienssen and Kristin Schirmer's comments regarding ?Toxicological relevance of emerging contaminants for drinking water quality Water Res. pp. 1515 - 1517
  • AA Jensen, U Berger, IT Cousins, J Franklin, K Kannan, SPJ van Leeuwen, W.P. de Voogt, JM Conder, RC Buck, SA Mabury(2011): Perfluoroalkyl and polyfluoralkyl substances (PFASs) in the environment: terminology, classification, and origins. Integr. Environ. Assess. Manage. pp. 513 - 541
  • C Eschauzier, E.F. Beerendonk, P Scholte-Veenendaal, W.P. de Voogt(2012): Impact of treatment processes on the occurrence of perfluoroalkyl acids in the drinking water production chain. Environ. Sci. Technol. pp. 1708 - 1715
  • S Felizeter, M McLachlan, W.P. de Voogt(2012): Uptake of perfluorinated alkyl acids by hydroponically grown lettuce (Lactuca sativa) Environ Sci Technol pp. 11735 - 11743
  • E Dellatte, G Brambilla, SP de Filippis, A di Domenico, J Pulkrabova, C Eschauzier, S Klenow, G Heinemeyer, W.P. de Voogt(2013): Occurrence of selected perfluorinated alkyl acids in lunch meals served at school canteens in Italy and their relevance for children?s intake. Food Addit. Contam pp. 1590 - 1597
  • C Eschauzier, KJ Raat, PJ Stuyfzand, W.P. de Voogt(2013): Perfluorinated alkylated acids in groundwater and drinking water: identification, origin and mobility Sci total Environ pp. 477 - 485
  • C Eschauzier, M Hoppe, M Schlummer, W.P. de Voogt(2013): Presence and sources of anthropogenic perfluorinated alkyl acids in tap-water based beverages. Chemosphere pp. 36 - 41
  • J Brulik, Z Simek, W.P. de Voogt(2013): A new liquid chromatography ? tandem mass spectrometry method using atmospheric pressure photo ionization for simultaneous determination of azaarenes and azaarones in Dutch river sediments J. Chromatogr. A pp. 33 - 40
  • SL Waaijers, J Hartmann, Soeter AM, R Helmus, SAE Kools, W.P. de Voogt, W Admiraal, JR Parsons, MHS Kraak(2013): Toxicity of New Generation Flame Retardants to Daphnia magna. Sci. Total Environ. pp. 1042 - 1048 ISSN: 0048-9697.

Publications for the general public

  • Zie bijlage
  • P. de Voogt, Y. Chen, A. van Roon(2006): Determination of environmental behaviour of perfluorinated alkylated substances using QTrap LC-MS/MS
  • P. de Voogt, H.B. Krop(2006): Sorption of surfactants to marine sediments
  • P. de Voogt, M. Sáez, P. Serné, W. Fahner, A. van Roon(2006): Perfluorinated alkulated substance in surface waters of the Netherlands
  • M. Sáez, P. de Voogt, K. Parsons(2006): Polyfluorinated alkylated substances in sludge and sediment: do they biodegrade?
  • P. de Voogt(2006): New emerging contaminants: the case of the perfluorinated alkylated substances
  • A. van Roon, W. Fahner, K.I. van de Vijver, P. de Voogt(2006): The partitioning of PFAS between water, sediment and particulate matter in field and laboratory experiments
  • P. de Voogt(2006): Newly emerging compounds: old or new science?
  • P. de Voogt(2006): Perfluorinated organic compounds in the European environment - Achievements of the PERFORCE project
  • J.G.M. Derksen, E.J.T.M. Leenen, J.H. Roorda, P.J. Roeleveld, M.H. Lamoree, A. van der Horst, P. de Voogt, A. van Roon, H.T. Besselink, S. van der Linden, C.A. Uijterlinde(2006): Exploratory monitoring of endocrine disruptors and pathogens in sewage treatment plants with additional treatment steps
  • P. de Voogt, A. van Roon(2007): Sewage treatment plants are possible sources of perfluorinated organic compounds in the European environment
  • P. de Voogt(2007): Modern extraction methods for organics in environmental analytical chemistry
  • M. Mons, A. van Roon, P. de Voogt(2007): Perfluoroalkylated substances in Dutch drinking water sources
  • J.G.M. Derksen, E.J.T.M. Leenen, J.H. Roorda, P.J. Roeleveld, M.H. Lamoree, A. van der Horst, P. de Voogt, A. van Roon, H.T. Besselink, S. van der Linden, C.A. Uijterlinde(2007): Exploratory monitoring of endocrine disruptors and pathogens in sewage treatment plants with additional treatment steps
  • P. de Voogt(2007): Perforce: perfluorinated organic compounds In the European environment
  • P. de Voogt(2007): Emerging tools for water monitoring
  • J.R. Parsons, E. Skoczynska, H. Djuma, P. de Voogt(2007): Debromination of PBDEs in anaerobic sediment microcosms
  • J. Legler, M. van Velzen, P. Cenijn, P. de Voogt, C. Houtman, M. Lamoree, J.W. Wegener(2008): Effect-directed analysis of municipal landfill soil reveals teratogenic compounds in the zebrafish Danio rerio
  • S. Cerbin, E. van Donk, M. Kraak, P. de Voogt, P. Visser(2008): The effects of multiple stressors on Daphnia; VIII International Symposiun on Cladocera
  • P. de Voogt, F. Sacher, M.-L. Janex-Habibi, A. Bruchet, L. Puijker, M. Mons(2008): Development of an international priority list of pharmaceuticals relevant for the water cycle
  • N. Johansson, D. Benford, A. Carere, J. de Boer, P. de Voogt, A. di Domenico, D. Schrenk, G. Schoeters(2008): Opinion of the Scientific Panel on Contaminants in the Food Chain on PFOS, PFOA and their salts
  • P. de Voogt, F.W.M. van der Wielen, J. Westerveld, W. D'Hollander, L. Bervoets(2008): Determination of perfluorinated organic compounds in food and dust
  • P. de Voogt, L. Zurano, P. Serné(2008): Partition coefficients using HPLC techniques to determine hydrophobicity of perfluorinated organic compounds

Details

Project number

834.05.002

Main applicant

Prof. dr. W.P. de Voogt

Affiliated with

Universiteit van Amsterdam, Faculteit der Natuurwetenschappen, Wiskunde en Informatica, Institute for Biodiversity and Ecosystem Dynamics - IBED

Duration

01/02/2005 to 17/09/2012