Food2Learn: Effect of omega-3 LCPUFA intervention on learning, cognition, behaviour and visual processing

Summary

The brain is primarily developed in the third trimester of pregnancy, but continues maturing through the late twenties, especially the prefrontal cortex. Omega-3 long-chain polyunsaturated fatty acids (LCPUFA) are important structural components of neural cell membranes, influence membrane fluidity and signal transduction, and thus learning, cognition and behaviour. Levels of omega-3 LCPUFA have been found to be low in individuals with limitations in these complex brain functions. Previous studies suggested that such functions could be improved by increasing LCPUFA. The adolescent brain, however, has been largely neglected.
This study investigates the effect of one-year daily omega-3 LCPUFA supplementation, in particular krill oil, in healthy 14-15 year old adolescents in lower general secondary education (MAVO/VMBO) on learning, cognition, and behaviour. The majority of the omega-3 PUFA in krill oil is incorporated into phospholipids, favouring tissue uptake of its omega-3 PUFA.
In a double blind, randomised controlled trial, 300 adolescents preselected from a population of 700 adolescents with low omega-3 index (<5%) will receive daily omega-3 LCPUFA supplementation or matching placebo. The omega-3 LCPUFA dose will be adjusted individually to reach a target level of 8-11%. The effects on learning (academic achievement, objective cognitive performance), behaviour (mood, self-esteem, motivation, goal-orientation, absenteeism), and in a subsample cognitive processes, in particular perceptual processes measured by eye-tracking will be evaluated after 6, 12, and 24 months.
This study will yield important insights in the effects of omega-3 LCPUFA supplementation, a safe intervention, on a large variety of complex brain functions

Output

Thesis

  • Beoogd: proefschrift
  • ISM van der Wurff(2018): Fatty Acids, Cognition, School Performance, and Mental Well-Being in Children and Adolescents , Maastricht  February 9, 2018

Scientific article

Publication meant for a broad audience

  • (2015): Wetenschappers doen onderzoek op De Nassau in Breda

Publications for the general public

  • I.S.M. van der Wurff, P.A. Kirschner, R.H.M. de Groot(2013): Nutrition and the Brain.
  • R.H.M. de Groot, I.S.M. van der Wurff, M. Broens, P.A. Kirschner(2013): Food2Learn.
  • R.H.M. de Groot(2013): Adolescent Brain
  • R.H.M. de Groot, I.S.M. van der Wurff, M. Broens, P.A. Kirschner(2013): Food2Learn.
  • I.S.M. van der Wurff, P.A. Kirschner, R.H.M. de Groot(2013): Nutrition and the Brain.
  • R.H.M. de Groot, I.S.M. van der Wurff, M. Broens, P.A. Kirschner(2014): Adolescents and brain development.
  • I.S.M. van der Wurff, M. Broens, P.A. Kirschner, R.H.M. de Groot(2014): Food2Learn.
  • R.H.M. de Groot, I.S.M. van der Wurff, M. Broens, P.A. Kirschner(2014): Adolescents and brain development.
  • R.H.M. de Groot, I.S.M. van der Wurff, M. Broens, P.A. Kirschner(2014): Food2Learn.
  • RHM de Groot(2014): Organizing satellite symposium ‘Maternal and Infant Health
  • R.H.M. de Groot, I.S.M. van der Wurff, M. Broens, P.A. Kirschner(2014): Adolescents and brain development.
  • I.S.M. van der Wurff, M. Broens, P.A. Kirschner, R.H.M. de Groot(2014): Nutrition and the Brain.
  • R.H.M. de Groot, I.S.M. van der Wurff, M. Broens, P.A. Kirschner(2014): Food2Learn.
  • R.H.M. de Groot, I.S.M. van der Wurff, M. Broens, P.A. Kirschner(2014): Adolescents and brain development
  • ISM van der Wurff, M Broens, P.A. Kirschner, RHM de Groot(2014): Nutrition and the Brain.
  • ISM van der Wurff, EC Bakker, G Hornstra, PA Kirschner, M Zeegers, RHM de Groot(2014): Relation between current and early LCPUFA exposure on academic achievements at age 7:
  • ISM van der Wurff, C von Schacky, K Berge, PA Kirschner, RHM de Groot(2014): Food2Learn: Randomized controlled trial investigating influence of krill oil supplementation on learning,cognition, and behaviour in healthy adolescents. Design presentation
  • R.H.M. de Groot, I.S.M. van der Wurff, M. Broens, P.A. Kirschner(2014): Adolescents and brain development.
  • A. van der Wurff, M. Broens, P.A. Kirschner, R.H.M. de Groot(2014): Adolescents and brain development.
  • R.H.M. de Groot, I.S.M. van der Wurff, M. Broens, P.A. Kirschner(2014): Adolescents and brain development.
  • M. Broens, I.S.M. van der Wurff, P.A. Kirschner, R.H.M. de Groot(2014): Food2Learn
  • R.H.M. de Groot, I.S.M. van der Wurff, M. Broens, P.A. Kirschner(2014): Food2Learn.
  • I.S.M. van der Wurff, M. Broens, P.A. Kirschner, R.H.M. de Groot(2014): Food2Learn.
  • R.H.M. de Groot, I.S.M. van der Wurff, M. Broens, P.A. Kirschner(2014): Adolescents and brain development
  • ISM van der Wurff, K Berge, M Zeegers, PA Kirschner, C von Schacky, RHM de Groot(2015): Association between omega-3 index and cognition, learning and behaviour in healthy adolescents: Preliminary results.
  • RHM de Groot(2015): Maastricht Essential Fatty Acid Birth Cohort (MEFAB), LCPUFA status and brain functioning.
  • RHM de Groot(2015): Visolie, wonderolie of slangengif?
  • RWL Godschalk, ISM van der Wurff, M Zeegers, M Gielen, PA Kirschner, G Hornstra, EC Bakker, RHM de Groot, S Kremers(2015): Association between prenatal and current LCPUFA exposure and school performance at age 7.
  • I.S.M. van der Wurff, P.A. Kirschner, R.H.M. de Groot(2015): Nutrition and the Brain.
  • R.H.M. de Groot(2015): Adolescents and the brain
  • R.H.M. de Groot, I.S.M. van der Wurff, M. Broens, P.A. Kirschner(2015): Adolescents and brain development
  • RHM de Groot(2015): LCPUFA status and brain functioning
  • ISM van der Wurff(2016): Food2Learn: Effect of 1 year krill oil supplementation on mental well-being in typically developing Dutch adolescents.
  • PA Kirschner, RHM de Groot, ISM van der Wurff(2016): Voeding & het brein [Nutrition & the brain]
  • RHM de Groot(2016): Massive Online Course Puberbrein
  • PA Kirschner, ISM van der Wurff, RHM de Groot(2016): Voeding & het brein [Nutrition & the brain]
  • RHM de Groot(2016): Omega-3 Vetzuren en psychologisch functioneren
  • RHM de Groot(2016): Lessons learnt in a double-blind randomized controlled krill oil intervention study in healthy adolescents on learning, cognition, and behaviour.
  • RHM de Groot, T Bergeland, PA Kirschner, R Leontjevas, C von Schacky, ISM van der Wurff(2016): Effect of 1 year krill oil supplementation on cognitive achievement in typically developing Dutch adolescents: Preliminary results
  • RHM de Groot, ISM van der Wurff, R Leontjevast, T Bergeland, C von Schacky, PA Kirschner(2017): Effect of 1 year krill oil supplementation on mental well-being in typically developing Dutch adolescents.
  • ISM van der Wurff(2018): Fatty Acids, Cognition, School Performance, and Mental Well-Being in Children and Adolescents

Details

Project number

057-13-002

Main applicant

Prof. dr. R.H.M. de Groot

Affiliated with

Open Universiteit, Faculteit Psychologie en onderwijswetenschappen, Welten-instituut

Team members

Drs. M. Broens, Drs. D.L. Hofman, Drs. A. Weber, I.S.M. van der Wurff MSc

Duration

21/10/2013 to 13/03/2018