EUROCORES Science of Protein Production for Structural and Functional Analysis (EuroSCOPE)

Deze EUROCORES wordt uitgevoerd in samenwerking tussen de NWO-gebieden CW/ACTS en ALW

De volgende 12 funding agencies werken samen in deze EUROCORES: Oostenrijk, Belgie, Tsjechie, Estland, Finland, Griekenland, Ierland, Portugal, Slowakije, Spanje, Zweden en Nederland.

Scientific goals: The programme intends to tackle the major stumbling blocks in the production of proteins for functional and structural analysis. The focus will be on the basic understanding of the mechanisms underlying protein production, targeting, folding and stability, which eventually may result in the improvement of existing and the design of new expression systems. The work should lead to a firm foundation for the rational engineering of strains for the production of complex proteins such as multi-domain eukaryotic proteins, integral membrane proteins and multi-enzyme complexes. Thus far, these complex systems are highly underrepresented in the protein structure databases, because they are difficult to overproduce in a functional form and in amounts suitable for functional and structural work.

The emphasis of the programme is on the science of all aspects of protein production to permit structural studies of complex systems to begin. The program will not fund projects that aim at scaling up of the processes or the setting up of protein factories for the production on demand, although such initiatives will benefit from basic knowledge of protein production as proposed here. In Phase II of the programme, the structural analysis of the complex protein systems will become more prominent as this is evidently the second major hurdle in the exploitation of the wealth of genomic information currently available.

Extra Informatie

De Call is intussen gesloten en er zijn 3 projecten met in totaal 23 deelprojecten gehonoreerd. Aan 4 van deze deelprojecten nemen Nederlandse onderzoekers deel.

Criteria

Niet langer van toepassing.

Contactpersonen

• Dhr. dr. Th. Bruhn (Programma co-ordinator EuroSCOPE)
  

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